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Open Access Highly Accessed Case study

Suspected acute exacerbation of idiopathic pulmonary fibrosis associated with interferon alpha therapy for hepatitis C: case report

Victoria Yee-May Ling1*, Marianne Mortimore2 and David J Serisier134

Author Affiliations

1 Department of Respiratory Medicine, Mater Adult Hospital, South Brisbane, Qld, 4101, Australia

2 Department of Gastroenterology, Mater Adult Hospital, South Brisbane, Qld, Australia

3 University of Queensland, Mater Health Services, South Brisbane, Qld, Australia

4 Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Qld, Australia

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SpringerPlus 2013, 2:101  doi:10.1186/2193-1801-2-101

Published: 12 March 2013

Abstract

Interferon alpha (IFNα) has immune stimulatory actions implicated in its pulmonary toxicities. We describe deterioration of idiopathic pulmonary fibrosis (IPF) associated with IFNα treatment for chronic hepatitis C in a 58 year old woman culminating in a fatal suspected acute exacerbation of IPF (AE-IPF). Caution should be exercised in the use of IFNα in subjects with concomitant IPF given its known immunostimulatory effects and possible role in this suspected AE-IPF.

Keywords:
Idiopathic pulmonary fibrosis / usual interstitial pneumonia; Acute exacerbation of idiopathic pulmonary fibrosis; Interferon alpha; Hepatitis C