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Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits

Alexander O Tarakanov1* and Kjell G Fuxe2

Author Affiliations

1 Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation, Saint Petersburg, Russia

2 Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

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SpringerPlus 2013, 2:128  doi:10.1186/2193-1801-2-128

Published: 22 March 2013


Based on our theory, main triplets of amino acid residues have been discovered in cell-adhesion receptors (integrins) of marine sponges, which participate as homologies in the interface between two major immune molecules, MHC class I (MHCI) and CD8αβ. They appear as homologies also in several human neural receptor heteromers and subunits. The obtained results probably mean that neural and immune receptors also utilize these structural integrin triplets to form heteromers and ion channels, which are required for a tuned and integrated intracellular and intercellular communication and a communication between cells and the extracellular matrix with an origin in sponges, the oldest multicellular animals.

Neural receptor-receptor interactions; Receptor interface; Marine sponges; Triplet homologies