Open Access Research

Clinicopathological characteristic and clinical handling of the patients with 2 cm or less gastric GISTs

Mikinori Kataoka1*, Takashi Kawai2, Hidekazu Ikemiyagi1, Takashi Fujii1, Mari Fukuzawa3, Masakatsu Fukuzawa2, Keisuke Kubota4, Masashi Yoshida4, Shinji Suzuki1 and Masaki Kitajima4

Author Affiliations

1 Department of Gastroenterology and Hepatology, International University Of Health and Welfare Mita Hospital, 1-4-3 Mita, Minatoku, Tokyo 108-8329, Japan

2 Endoscopy Center, Tokyo Medical University Hospital, Tokyo Japan

3 Department of Gastroenterology and Hepatology, Tokyo Medical University Hospital, Tokyo Japan

4 Department of Gastroenterological Surgery, International University Of Health and Welfare Mita Hospital, Tokyo Japan

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SpringerPlus 2013, 2:469  doi:10.1186/2193-1801-2-469

Published: 17 September 2013

Abstract

Background

We previously reported that safety and efficacy of mucosal cutting biopsy for diagnosing included 2 cm or less gastric GISTs. However, there have been no reports stating the clinicopathological characteristic and clinical handling of the patients with 2 cm or less gastric GISTs. The aim of our study is to investigate the clinicopathological characteristic and clinical handling of the patients with 2 cm or less gastric GISTs.

Methods

The 19 patients diagnosed with GIST by mucosal cutting biopsy were divided into 2 groups: Group I; subjects were GISTs with 2 cm or less, Group II; subjects were GISTs >2 cm. We compared the 2 groups in terms of mean age, tumor size, tumor site, histopathological risk grade. In cases that underwent surgery with a diagnosis of GIST, we compared the pre- and postoperative histopathological diagnosis, and the histopathlogical risk grade within each group.

Results

The mean age and tumor size were significantly higher in Group I than in Group II. Meanwhile, there were no significant differences between the 2 groups, sex ratio, tumor site. All lesions were at histopathological risk grade at very low risk and low risk respectively. In 17 patients with GIST who underwent surgery, the histopathological diagnoses, immunostaining were in agreement with those from the mucosal cutting biopsy specimens in all cases, but mitotic count of one patient was not in agreement in group II.

Conclusions

The 2 cm or less gastric GISTs diagnosed with histpathlogical very low risk can be considered acceptable to follow-up.

Keywords:
Submucosal tumors; Gastrointestinal stromal tumors; Endoscopic mucosal cutting biopsy