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Open Access Case study

Fusarium napiforme systemic infection: case report with molecular characterization and antifungal susceptibility tests

Marcela de Souza14*, Tetsuhiro Matsuzawa2, Luzia Lyra3, Ariane Fidelis Busso-Lopes1, Tohru Gonoi2, Angélica Zaninele Schreiber3, Katsuhiko Kamei2, Maria Luiza Moretti1 and Plínio Trabasso1

Author Affiliations

1 Department of Internal Medicine, School of Medicine, University of Campinas, Campinas, São Paulo, Brazil

2 Medical Mycology Research Center, Chiba University, Chiba, Japan

3 Department of Clinical Pathology, School of Medicine, University of Campinas, Campinas, São Paulo, Brazil

4 LIM 46 – Laboratory of Parasitology – HC/FMUSP, São Paulo, Brazil

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SpringerPlus 2014, 3:492  doi:10.1186/2193-1801-3-492

Published: 30 August 2014

Abstract

Introduction

During the last decades, Fusarium spp. has been reported as a significant cause of disease in humans, especially in immunocompromised patients, who have high risk of invasive life-threatening disease. Fusarium species usually reported as cause of human disease are F. solani, F. oxysporum and F. verticillioides.

Case description

We describe the second case in the literature of disseminated fusariosis caused by Fusarium napiforme, that occurred in a 60-year-old woman with multiple myeloma after subsequent cycles of chemotherapy.

Discussion and Evaluation

We identified the F. napiforme not only by standard morphologic criteria by macroscopic and microscopic characteristics, but also confirmed by molecular biology methods, including sequencing. The antifungal susceptibility of the F. napiforme isolates were tested to seven antifungal drugs; the azoles were the most active drug against all the isolates tested.

Conclusions

Fusarium spp. are of relevance in medical mycology, and their profiles of low susceptibility to antifungal drugs highlight the importance for faster and more accurate diagnostic tests, what can contribute to an earlier and precise diagnosis and treatment.

Keywords:
Fusariosis; Opportunistic Infections; Immunocompromised host